Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134390" target="_blank" >RIV/00216208:11140/13:10134390 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/13:10134390

Result on the web

<a href="http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2013N03A0291" target="_blank" >http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2013N03A0291</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

Original language description

Our aim was to quantify histological postoperative changes of AAA in porcine experimental model of AAA with and without administration of atorvastatin. The AAA was induced by intraaortic infusion of porcine pancreatic elastase and subrenal application ofplastic cuff. The AAA statin group (n=14) received atorvastatin 1 mg/kg daily for 28 days, the other AAA group (n=13) did not. The aortic diameter was measured by ultrasonography. Aortic samples were described using eleven quantitative histological parameters and compared with healthy aortae. There was no difference in aortic diameter between the AAA with statin when compared to AAA without statin. Administration of atorvastatin led to a better postoperative histological condition of the aortic elastinnetwork, preservation of contractile phenotype of vascular smooth muscle, a higher density of vasa vasorum, it prevented thickening of intima and media. The increase in wall thickness in AAA without atorvastatin has not been accompanied

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/NS10235" target="_blank" >NS10235: Tendency for a pharmacological influencing of an experimental AAA growing in an animal.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Angiology

ISSN

0392-9590

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

3

Country of publishing house

IT - ITALY

Number of pages

16

Pages from-to

291-306

UT code for WoS article

000322750400004

EID of the result in the Scopus database

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