Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10138961" target="_blank" >RIV/00216208:11140/13:10138961 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25" target="_blank" >http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2013.03.034" target="_blank" >10.1016/j.neulet.2013.03.034</a>

Result language
angličtina
Original language name
Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice
Original language description
DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO r
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)