The influence of chronic administration of thioacetamide on levels of ALT, AST and GLDH in serum and markers of oxidative stress in the liver and kidneys of female Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10139295" target="_blank" >RIV/00216208:11140/13:10139295 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of chronic administration of thioacetamide on levels of ALT, AST and GLDH in serum and markers of oxidative stress in the liver and kidneys of female Wistar rats

Original language description

Background. Thioacetamide (TAA), a well known inducer of hepatic fibrosis, has been often used in experimental acute and chronic hepatotoxicity models. Reactive oxygen species play an important role in TAA-induced liver damage. Aims. To study the time course of activities of ALT, AST and GLDH in serum and markers of oxidative stress in the liver and kidneys of rats after chronic TAA administration. Methods. Female Wistar rats were treated with TAA (intraperitoneally, 200 mg/kg body weight) for 12 weeks,the controls received saline. Animals were sacrificed 4, 12 or 16 weeks after the treatment discontinuation. Lipid peroxidation (LP), reduced glutathione (GSH) and activities of glutathione peroxidase (GPx), glutathione reductase (GR) and katalase (CAT)were estimated in the liver and kidneys. ALT, AST and GLDH were measured in serum. Results. Significant increases in serum ALT and GLDH persisted for 16 weeks ater the treatment, while serum AST was increased only in animals sacrificed 4

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

Supplement 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

"S65"-"S69"

UT code for WoS article

000324728600005

EID of the result in the Scopus database

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