Possible prooxidant effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1) antagonists in neural tissue

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10193031" target="_blank" >RIV/00216208:11140/13:10193031 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Possible prooxidant effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1) antagonists in neural tissue

Original language description

Angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1) antagonists (ARBs, sartans) are widely used for treatment of cardiovascular diseases. Many findings suggest they also have a potent ability to protect tissues againstthe damage associated with oxidative stress. Contrary to these results, our experiments show ACE inhibitors and sartans may have some prooxidant activity, mainly in neural tissue. Male Wistar rats were treated orally once daily for 3 days with captoril(50 mg/kg), losartan (20 mg/kg), or telmisartan (10 mg/kg). All substances were given by gastric gavages, dispersed in methylcellulose. Animals in the control group received methylcellulose only. On the fourth day, parameters of oxidative state: lipid peroxidation (thiobarbituric acid reactive substances), reduced glutathione (GSH) and activity of antioxidant enzymes glutathione peroxidase and glutathione reductase were estimated in liver and brain homogenates. Administration of captopri

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Plzeňský lékařský sborník

ISSN

0551-1038

e-ISSN

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Volume of the periodical

2013

Issue of the periodical within the volume

79

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

43-48

UT code for WoS article

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EID of the result in the Scopus database

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