Atypical epithelioid cell myofibroblastoma of the breast with multinodular growth pattern: A potential pitfall of malignancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10193242" target="_blank" >RIV/00216208:11140/13:10193242 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.prp.2013.04.008" target="_blank" >http://dx.doi.org/10.1016/j.prp.2013.04.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prp.2013.04.008" target="_blank" >10.1016/j.prp.2013.04.008</a>

Result language

angličtina

Original language name

Atypical epithelioid cell myofibroblastoma of the breast with multinodular growth pattern: A potential pitfall of malignancy

Original language description

Myofibroblastoma (MFB) of the breast is the prototypical benign spindle cell tumor arising from the mammary stroma. Over the last two decades, several morphological variants of this tumor have been recognized. Epithelioid cell MFB is composed predominantly of neoplastic elements with epithelioid morphology. It represents a potential diagnostic pitfall of malignancy, especially when evaluating small biopsies. We report a unique case of a mammary epithelioid cell MFB composed of large mono- to multi-nucleated cells showing mild to moderate nuclear pleomorphism, predominantly arranged in a multinodular growth pattern. This tumor needs to be distinguished from invasive apocrine, oncocytic, pleomorphic lobular carcinoma, as well as metastases. Immunohistochemistry revealed the fibroblastic/myofibroblatic (positivity for vimentin, desmin, CD34 and focally for alpha-smooth muscle actin) nature of proliferating cells, and therefore was crucial for a correct diagnosis. (C) 2013 Published by Els

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathology Research and Practice

ISSN

0344-0338

e-ISSN

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Volume of the periodical

209

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

463-466

UT code for WoS article

000323235800013

EID of the result in the Scopus database

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