Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke : Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10173982" target="_blank" >RIV/00216208:11140/14:10173982 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00060926 RIV/00669806:_____/14:10173982
Result on the web
<a href="http://stroke.ahajournals.org/content/45/1/176" target="_blank" >http://stroke.ahajournals.org/content/45/1/176</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002133" target="_blank" >10.1161/STROKEAHA.113.002133</a>

Result language
angličtina
Original language name
Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke : Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register
Original language description
Background and Purpose-Temporal variations of thrombolysis delivery and their influence on outcome have been reported with controversial results. In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome. Methods-We retrospectively analyzed patients with acute ischemic stroke receiving intravenous alteplase, prospectively included in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. Patients were grouped by treatment on day hours (08:00-19:59) or night hours (20:00-07:59) and treatment on weekdays and weekends. For each subgroup, we analyzed frequency of thrombolytic treatments, time intervals, and outcomes (3-month modified Rankin Scale score 0-2 as good functional outcome, mortality, symptomatic intracerebral hemorrhage). Results-We included 21 513 patients. Considerin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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