Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10196137" target="_blank" >RIV/00216208:11140/14:10196137 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1113/jphysiol.2013.262626" target="_blank" >http://dx.doi.org/10.1113/jphysiol.2013.262626</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1113/jphysiol.2013.262626" target="_blank" >10.1113/jphysiol.2013.262626</a>

Result language
angličtina
Original language name
Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels
Original language description
We demonstrated dopamine, noradrenaline and adrenaline in rat aorta and superior mesenteric arteries by radioimmunoassay. Chemical sympathectomy did not affect tissue dopamine levels. Isolated endothelial cells were able to synthesise and release dopamine upon cAMP stimulation. Endothelial and smooth muscle cells expressed catecholaminergic traits (RT-PCR, WB). Exposure of endothelial cells to hypoxia (1% O2) increased tyrosine hydroxylase mRNA. Hypoxic vasodilatation was abrogated by receptor D1-antagonist. In conclusion, endothelial cells and cells of the underlying vascular wall synthesize and release dopamine in an oxygen-regulated manner.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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