New Treatment Paradigm for Patients with Anaplastic Oligodendroglial Tumors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10210717" target="_blank" >RIV/00216208:11140/14:10210717 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/14:10210717

Result on the web

<a href="http://ar.iiarjournals.org/content/34/4/1587.full.pdf+html" target="_blank" >http://ar.iiarjournals.org/content/34/4/1587.full.pdf+html</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New Treatment Paradigm for Patients with Anaplastic Oligodendroglial Tumors

Original language description

Oligodendrogliomas are uncommon tumors in neurooncology that represent about 5% of primary brain malignancies. their high sensitivity to radiotherapy and chemotherapy was observed a long time ago. Nonetheless, the evidence-based proof of the hisnificantly longer survival in patients with oligodendrogliomas treated with combined chemotheray and radiotherapy in comparison to radiootherapy-alone did not exist. The long-term follow-up of two landmark phase III clinical trials: RTOG 9402 and EORTC 26951, recently demonstrated favorable effects of combined radiotherapy and chemotherapy (procarbazine, lomustine and vincristine) in patients with anaplastic oligodendrolglionas and anaplastic oligoastrocytomas carrying the chromosomal mutation of co-deletion of1 p/19q. There is also and increasing role of other molecular bionarkers, such as mutations in the metabolic enzyme isocitrate dehydrogenase 1/2, o6-methylguanine DNA methyltransferase gene promotor methylation, or glioma genome cytosine-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

1587-1594

UT code for WoS article

000334089200014

EID of the result in the Scopus database

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