Asymmetric Dimethylarginine and Progression of Chronic Kidney Disease - a One-Year Follow-Up Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10271856" target="_blank" >RIV/00216208:11140/14:10271856 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1159/000355776" target="_blank" >http://dx.doi.org/10.1159/000355776</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000355776" target="_blank" >10.1159/000355776</a>
Alternative languages
Result language
angličtina
Original language name
Asymmetric Dimethylarginine and Progression of Chronic Kidney Disease - a One-Year Follow-Up Study
Original language description
Background/Aims: Asymmetric dimethylarginine (ADMA) is a prognostic factor in patients with chronic kidney disease (CKD). However, the relationships among factors influencing the metabolism of ADMA and the CKD progression are not fully understood. Methods: Serum ADMA, and variables related to the metabolism of ADMA were measured in 181 non-dialysis patients (CKD stages 3-5) and in 46 controls. Patients were assessed at baseline, and 6 and 12 months after the initiation of the study. Results: Patients had increased baseline ADMA, advanced glycation end products (AGE), and advanced oxidation protein products (AOPP) compared with controls (P < 0.001). In a total of 164 patients who completed a one-year study, the estimated GFR (eGFR) declined from 23.5 (17.7-36) mL/min/1.73m(2) to 21 (14.7-31.5) (P=0.018), AGE rose from 1.58 (1.38-1.90) mu mol/L to 1.76 (1.52-2.21) (P < 0.001), while ADMA, AOPP, tubular function, and proteinuria remained stable. In a multiple regression model (adjusted R-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Kidney and Blood Pressure Research
ISSN
1420-4096
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
50-57
UT code for WoS article
000339398300006
EID of the result in the Scopus database
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