Targeted next-generation sequencing and non-coding RNA expression analysis fo clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10281774" target="_blank" >RIV/00216208:11140/14:10281774 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/path.4296/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/path.4296/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/path.4296" target="_blank" >10.1002/path.4296</a>

Result language

angličtina

Original language name

Targeted next-generation sequencing and non-coding RNA expression analysis fo clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes

Original language description

Clear cell tubulopapillary renal cell carcinoma (CCPRCC) is a recently described rare renal malignancy that displays characteristic gross, microscopic and immunohistochemical differences from other renal tumour types. However, CCPRCC remains a very poorly understood entity. We therefore sought to elucidate some of the molecular mechanisms involved in this neoplasm by carrying out targeted next-generation sequencing (NGS) to identify associated mutations, and in addition examined the expression of non-coding (nc) RNAs. We identified multiple somatic mutations in CCPRCC cases, including a recurrent [3/14 cases (21%)] non-synonymous T992I mutation in the MET proto-oncogene, a gene associated with epithelial-to-mesenchymal transition (EMT). Using a microarray approach, we found that the expression of mature (n = 1105) and pre-miRNAs (n = 1105), as well as snoRNA and scaRNAs (n = 2214), in CCPRCC cases differed from that of clear cell renal cell carcinoma (CCRCC) or papillary renal cell car

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pathology

ISSN

0022-3417

e-ISSN

—

Volume of the periodical

232

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

32-42

UT code for WoS article

000327900800005

EID of the result in the Scopus database

—