Chromophobe renal cell carcinoma with neuroendocrine differentiation / morpohology: a clinicopathological and genetic study of three cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10283815" target="_blank" >RIV/00216208:11140/14:10283815 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/14:10283815

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S2214330014200174#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2214330014200174#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ehpc.2014.08.003" target="_blank" >10.1016/j.ehpc.2014.08.003</a>

Result language

angličtina

Original language name

Chromophobe renal cell carcinoma with neuroendocrine differentiation / morpohology: a clinicopathological and genetic study of three cases

Original language description

Chromophobe renal cell carcinoma (ChRCC) with neuroendocrine differentiation/ morphology (NED/NEM) is exceedingly rare. We present three cases of ChRCC with NED/NEM, two of which showed positivity for neuroendocrine markers on immunohistochemical analysis. Patients ranged in age from 49 to 79 years (mean: 64.3 years). One of the three patients died of metastatic disease to multiple organs. Of the remaining two patients, one is currently alive without disease and the other is alive with disease. Histologically, all three tumors were composed of conventional ChRCC and NEM showed glandular and rosette formation. Immunohistochemically, tumor cells were positive for CK7, KAI1, E-cadherin, and c-kit in both ChRCC and neuroendocrine areas in three cases. CD56and synaptophysin immunoreactivity were detected in two cases; in only the neuroendocrine area in one case and in both components in the other. Neuroendocrine granules were ultrastructurally observed at both neuroendocrine and convention

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Pathology

ISSN

0046-8177

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

31-39

UT code for WoS article

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EID of the result in the Scopus database

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