HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10293439" target="_blank" >RIV/00216208:11140/14:10293439 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/14:10293439
Result on the web
<a href="http://www.bloodjournal.org/content/bloodjournal/124/26/3996.full.pdf" target="_blank" >http://www.bloodjournal.org/content/bloodjournal/124/26/3996.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2014-09-599969" target="_blank" >10.1182/blood-2014-09-599969</a>

Result language
angličtina
Original language name
HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation
Original language description
Life-threatening graft-versus-host disease (GVHD) limits the use of HLA-C-mismatched unrelated donors in transplantation. Clinicians lack criteria for donor selection when HLA-C-mismatched donors are a patient's only option for cure. We examined the rolefor HLA-Cexpressionlevels toidentifypermissibleHLA-Cmismatches.Themedian fluorescence intensity, a proxy of HLA-Cexpression,was assigned to each HLA-C allotype in 1975 patients and their HLA-C-mismatched unrelated transplant donors. The association of outcome with the levelofexpressionof patients'anddonors'HLA-Callotypeswasevaluated inmultivariable models. Increasing expression level of the patient's mismatched HLA-C allotype was associated with increased risks of grades III to IV acute GVHD, nonrelapse mortality, and mortality. Increasing expression level among HLA-C mismatches with residue 116 or residue 77/80 mismatching was associated with increased nonrelapse mortality. The immunogenicity of HLA-C mismatches in unrelated donor tra
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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