Assessment of Grading in Newly-diagnosed Glioma Using 18F-Fluorothymidine PET/CT

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10293632" target="_blank" >RIV/00216208:11140/15:10293632 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/15:10293632
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Assessment of Grading in Newly-diagnosed Glioma Using 18F-Fluorothymidine PET/CT
Original language description
Aim: To evaluate the proliferation activity in gliomas using 18F-fluorothymidine (18F-FLT)-positron emission tomography/computed tomography (PET/CT). Patients and Methods: Samples of 26 tumors were analyzed (mean age=51.6; range=26-72 years; 16 males, 10females). All examinations were performed using a PET/CT scanner equipped with lutetium oxyorthosilicate (LSO) detectors. All data were acquired with a delay of 15 min, following intravenous application of 18F-FLT (dosed 2 MBq/kg of body weight). The PET/CT contained CT after intravenous application of iodinated contrast agent and high-resolution brain PET acquired during 15 min in one position. PET/CT was performed before confirmation of the histological diagnosis and the level of 18F-FLT accumulationwas compared to the grading of the tumor evaluated using immunohistochemistry staining of Ki-67. Samples were obtained by stereotactic biopsy (5x) or surgical resection (21x). Results: Five tumors of grade IV, 7 tumors of grade III and 1
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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