Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10293645" target="_blank" >RIV/00216208:11140/15:10293645 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/15:10293645 RIV/00669806:_____/15:10293645

Result on the web

<a href="http://dx.doi.org/10.14670/HH-30.223" target="_blank" >http://dx.doi.org/10.14670/HH-30.223</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14670/HH-30.223" target="_blank" >10.14670/HH-30.223</a>

Result language

angličtina

Original language name

Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT

Original language description

Loss of expression of beta subunit of succinate dehydrogenase (SDHB) was proved to be present in a subgroup of KIT/PDGFRA wt gastrointestinal stromal tumors (GISTs). To evaluate possible diagnostic utility of SDHB immunohistochemistry in the differentialdiagnostics of mesenchymal tumors of gastrointestinal tract (GIT), 11 cases of KIT/PDGFRA wt GISTs, 12 gastric schwannomas (GSs), 20 solitary fibrous tumors (SFTs), 4 leiomyomas (LMs), 16 leiomyosarcomas (LMSs), 5 synovial sarcomas (SSs), 3 endometrioidstromal sarcomas (ESSs), and 1 ileal inflammatory myofibroblastic tumor (IMT) were investigated for SDHB immunoexpression together with molecular genetic analysis of genes encoding succinate dehydrogenase (SDH). Three recent cases of KIT/PDGFRA mutant GISTs were used as controls. Among the 11 KIT/PDGFRA wt GISTs, 6 expressed SDHB, 1 of them harboring a sequence change of SDHD. All SDHB-negative cases were SDHB-D wt. In 1 of the control GIST cases molecular genetic analysis revealed an S

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

<a href="/en/project/NT14227" target="_blank" >NT14227: Determining predictive factors for a therapeutic effect of chemotherapy in patients with stomach cancer</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Histology and Histopathology

ISSN

0213-3911

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

2

Country of publishing house

ES - SPAIN

Number of pages

10

Pages from-to

223-232

UT code for WoS article

000351201300010

EID of the result in the Scopus database

2-s2.0-84921000082