Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10294675" target="_blank" >RIV/00216208:11140/15:10294675 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.5114/pjp.2015.51147" target="_blank" >http://dx.doi.org/10.5114/pjp.2015.51147</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/pjp.2015.51147" target="_blank" >10.5114/pjp.2015.51147</a>

Result language

angličtina

Original language name

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Original language description

Rhabdoid morphology in renal cell carcinoma (RCC) may, like sarcomatoid change, be perceived as a type of dedifferentiation, and is a poor prognostic factor. Histologically, rhabdoid neoplastic cells are round to polygonal cells with globular eosinophilic cytoplasmic inclusions and eccentric vesicular nuclei and enlarged nucleoli. All types of RCC, including clear cell, papillary, chromophobe, collecting duct carcinoma, renal medullary carcinoma, acquired cystic disease-associated RCC, ALK-positive renal cancer and unclassified RCC, may display a variably prominent rhabdoid phenotype. Immunohistochemically, the cytoplasm of rhabdoid cells shows positivity for vimentin and/or cytokeratin. Ultrastructurally, cytoplasmic whorls/aggregates of intermediatefilaments correspond to light microscopically observed inclusions. Genetically, a previous report suggests that combined loss of BAP1 and PBRM1 may be associated with rhabdoid morphology. As with sarcomatoid change, pathologists should de

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polish Journal of Pathology

ISSN

1233-9687

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

3-8

UT code for WoS article

000354418400002

EID of the result in the Scopus database

2-s2.0-84929409541