Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10312475" target="_blank" >RIV/00216208:11140/15:10312475 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/15:10312475
Result on the web
<a href="http://dx.doi.org/10.1182/blood-2015-06-651562" target="_blank" >http://dx.doi.org/10.1182/blood-2015-06-651562</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2015-06-651562" target="_blank" >10.1182/blood-2015-06-651562</a>
Alternative languages
Result language
angličtina
Original language name
Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation
Original language description
To analyze the influence of distinct combinations ofmolecular aberrations on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for cytogenetically normal acute myeloid leukemia (CN-AML), a retrospective registry analysis was performed on 702 adults undergoing HSCT in first complete remission (CR). Patients were grouped according to presence or absence of NPM1 mutations (NPM1mut) and FLT3 internal tandem duplications (FLT3-ITD). Double-negative patients were evaluated for mutationsof the CCAAT/enhancer binding protein a gene (CEBPa). The influence of genotypes on relapse, non-relapse mortality, leukemia-free survival (LFS) and overall survival (OS), and a prognostic classification combining NPM1/FLT3-ITD profile and classical riskfactors were calculated. Two-year OS fromHSCTwas 8165% in NPM1mut/FLT3wt, 7563%in NPM1wt/FLT3wt, 6663%in NPM1mut/FLT3-ITD, and 54 6 7% in NPM1wt/FLT3-ITD (P 5 .003). Analysis of CEBPa among patients with NPM1wt/FLT3wt revealed excellent
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
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Volume of the periodical
126
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
2062-2069
UT code for WoS article
000366389200018
EID of the result in the Scopus database
2-s2.0-84944931277