Genome-wide methylation analysis of tubulocystic and papillary renal cell carcinomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10323598" target="_blank" >RIV/00216208:11140/16:10323598 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10323598 RIV/00669806:_____/16:10323598 RIV/00064165:_____/16:10323598

Result on the web

<a href="http://dx.doi.org/10.4149/309_151102N559" target="_blank" >http://dx.doi.org/10.4149/309_151102N559</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/309_151102N559" target="_blank" >10.4149/309_151102N559</a>

Result language

angličtina

Original language name

Genome-wide methylation analysis of tubulocystic and papillary renal cell carcinomas

Original language description

Tubulocystic renal cell carcinoma (TRCC) represents a rare tumor with incidence lower than 1 % of all renal carcinomas. This study was undertaken to contribute to characterization of molecular signatures associated with TRCC and to compare them with the features of papillary renal cell carcinoma (PRCC) at the level of genome wide methylation analysis.We performed methylated DNA immunoprecipitation (MeDIP) coupled with microarray analysis (Roche NimbleGen). Using the CHARM package, we compared the levels of gene methylation between paired samples of tumors and control renal tissues of each examined individual. We found significant global demethylation in all tumor samples in comparison with adjacent kidney tissues of normal histological appearance but no significant differences in gene methylation between the both compared tumor entities. Therefore we focused on characterization of differentially methylated regions between both tumors and control tissues. We found 42 differentially methylated genes.Hypermethylated genes for protocadherins (PCDHG) and genes coding for products associated with functions of plasma membrane were evaluated as significantly overrepresented among hypermethylated genes detected in both types of renal cell carcinomas.In our pilot study, we provide the first evidence that identical features in the process of carcinogenesis leading to TRCC and/or to PRCC may be found at the gene methylation level.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

63

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

402-410

UT code for WoS article

000377058000009

EID of the result in the Scopus database

2-s2.0-84969695615