Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10324237" target="_blank" >RIV/00216208:11140/16:10324237 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s13000-016-0505-3" target="_blank" >http://dx.doi.org/10.1186/s13000-016-0505-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13000-016-0505-3" target="_blank" >10.1186/s13000-016-0505-3</a>

Result language

angličtina

Original language name

Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease

Original language description

In summary, approximately one third of BD lesions in our Czech (Caucasian Eastern European) population are HPV-associated. In the HPV-positive lesions β- HPV genotypes predominated, although high- and low-risk mucosal HPV types were detected in a significant proportion of cases. The presence of the p16- expression, koilocyte-like change or papillomatosis is not predictive for the presence of neither α-HPV types nor β-HPV types in extragenital/extraungual Bowen's disease. Our study further supports the hypothesis that HPV infection might serve as an important co-factor in the carcinogenesis of BD and cSCC and identifies HPV 9 as a possibly significant β-HPV genotype with respect to mixed β-HPV infections and keratinocyte carcinogenesis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diagnostic Pathology

ISSN

1746-1596

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000379298800001

EID of the result in the Scopus database

2-s2.0-84975690964