Role of substance P in the cardiovascular system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10326718" target="_blank" >RIV/00216208:11140/16:10326718 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00100473
Result on the web
<a href="http://dx.doi.org/10.1016/j.npep.2015.12.005" target="_blank" >http://dx.doi.org/10.1016/j.npep.2015.12.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.npep.2015.12.005" target="_blank" >10.1016/j.npep.2015.12.005</a>
Alternative languages
Result language
angličtina
Original language name
Role of substance P in the cardiovascular system
Original language description
This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are mainly mediated through neurokinin receptor 1 since substance P is the ligand with the highest affinity to neurokinin receptor 1. Substance P is widely distributed within the central and peripheral nervous systems as well as in the cardiovascular system. Substance P is involved in the regulation of heart frequency, blood pressure and in the stretching of vessels. Substance P plays an important role in ischemia and reperfusion and cardiovascular response to stress. Additionally, it has been also implicated in angiogenesis, pain transmission and inflammation. The substance P/neurokinin receptor 1 receptor system is involved in the molecular bases of many human pathological processes. Antagonists of neurokinin receptor 1 receptor could provide clinical solutions for a variety of diseases. Neurokinin receptor 1 antagonists are already used in the prevention of chemotherapy induced nausea and vomiting.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuropeptides
ISSN
0143-4179
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
srpen
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
41-51
UT code for WoS article
000382414500006
EID of the result in the Scopus database
2-s2.0-84954290510