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Newly described salivary gland tumors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10330938" target="_blank" >RIV/00216208:11140/17:10330938 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.nature.com/modpathol/journal/v30/n1s/full/modpathol2016167a.html" target="_blank" >http://www.nature.com/modpathol/journal/v30/n1s/full/modpathol2016167a.html</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/modpathol.2016.167" target="_blank" >10.1038/modpathol.2016.167</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Newly described salivary gland tumors

  • Original language description

    This review concentrates on three salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma (MASC), sclerosing polycystic adenoma (SPA) and cribriform adenocarcinoma of tongue and other minor salivary glands (CAMSGs). MASC is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion. SPA is a rare lesion often mistaken histologically for low-grade salivary carcinoma. Previously thought to be a reactive fibroinflammatory process, but recent evidence of clonality, recurrences in up 30%, and dysplastic foci suggest it may be truly neoplastic. CAMSG is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma (PLGA) by location (ie, most often arising on the tongue), by prominent nuclear clearing, alterations of the PRKD gene family and clinical behavior with frequent metastases at the time of presentation of the primary tumor. Early metastatic disease seen in most cases of CAMSG associated with indolent behavior makes it a unique neoplasm among all low-grade salivary gland tumors. Salivary glands may give rise to a wide spectrum of different tumors. They are often diagnostically challenging as morphological features often overlap between different entities. Although conventional morphology in combination with immunohistochemical findings still provide the most important clues for diagnosis, recent advances in molecular pathology offer new diagnostic tools in investigating the differential diagnosis, as well as providing potentially valuable prognostic indicators. In the last two decades, several new salivary gland tumor entities have been described, namely MASC, SPA and CAMSGs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30109 - Pathology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Modern Pathology

  • ISSN

    0893-3952

  • e-ISSN

  • Volume of the periodical

    30

  • Issue of the periodical within the volume

    Supplement 1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    17

  • Pages from-to

    "S27"-"S43"

  • UT code for WoS article

    000391517900002

  • EID of the result in the Scopus database

    2-s2.0-85008659729