Impaired spatial performance in cerebellar-deficient Lurcher mice is not associated with their abnormal stress response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10359636" target="_blank" >RIV/00216208:11140/17:10359636 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.nlm.2017.02.009" target="_blank" >http://dx.doi.org/10.1016/j.nlm.2017.02.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nlm.2017.02.009" target="_blank" >10.1016/j.nlm.2017.02.009</a>

Result language

angličtina

Original language name

Impaired spatial performance in cerebellar-deficient Lurcher mice is not associated with their abnormal stress response

Original language description

Both humans and laboratory animals suffering from cerebellar lesions exhibit cognitive as well as many emotional and behavioral abnormalities. These latter have been already observed in the cerebellar mutant mice currently used to highlight some aspect of autism spectrum disorders. The aim of this study was to investigate the influence of cerebellar-related stress response abnormalities on spatial learning and memory. Cerebellar-deficient Lurcher mutant mice were exposed to water environment without active escape possibility and then tested for spatial learning in the Morris water maze. As a marker of stress intensity we measured corticosterone in urine. Finally, the volumes of individual components of the adrenal gland were estimated. Though having spatial navigation deficit in the water maze, Lurcher mice preserved a substantial residuum of learning capacity. Lurcher mutants had a higher increase of corticosterone level after exposure to the water environment than wild type mice. We did not observe any decrease of this physiological stress marker between the start and the end of the spatial navigation task, despite significant improvement of behavioral performances. Furthermore, zona fasciculata and zona reticularis of the adrenal cortex as well as the adrenal medulla were larger in Lurcher mice, reflecting high stress reactivity. We conclude that for both genotypes water exposure was a strong stressor and that there was no habituation to the experiment independently to the increasing controllability of the stressor (e.g. ability to find the escape platform). Based on these findings, we suggest that the enhanced stress response to water exposure is not the main factor explaining the spatial deficits in these cerebellar mutant mice.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurobiology of Learning and Memory

ISSN

1074-7427

e-ISSN

—

Volume of the periodical

140

Issue of the periodical within the volume

April

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

62-70

UT code for WoS article

000398646700008

EID of the result in the Scopus database

2-s2.0-85013361325