"Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10360300" target="_blank" >RIV/00216208:11140/17:10360300 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/17:10360300
Result on the web
<a href="https://link.springer.com/article/10.1007/s13167-017-0092-8" target="_blank" >https://link.springer.com/article/10.1007/s13167-017-0092-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13167-017-0092-8" target="_blank" >10.1007/s13167-017-0092-8</a>
Alternative languages
Result language
angličtina
Original language name
"Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question
Original language description
Breast cancer (BC) epidemic in the twenty-first century is characterised by around half a million deaths and 1.7 million new cases registered annually worldwide. Metastatic disease is the major cause of death in BC patient cohorts. Current statistics are much alarming from the viewpoint of the early mortality amongst BC patients with de novo metastatic disease. A new paradigm of so-called Bpre-metastatic niches^ may sufficiently promote our knowledge regarding potential pathomechanisms, individual predisposition and prognosis in development and progression of the metastatic disease. However, the crucial question remains unaddressed, whether hypoxic pre-metastatic niches in BC are created by or prior to the tumour onset. So far, the current interpretation of the BSeed and Soil^ theory of metastasis proposing that the pre-metastatic niches are formed by primary tumours which Binduce and guide^ the process is incomplete, since it does not provide satisfactory explanations towards several facts overviewed in the article. The overall results of this study clearly support the working hypothesis presented by the authors proposing that the epi/genetic predisposition of individuals at risk to form the systemic hypoxic premetastatic niches can be established a long time before breast malignancy is clinically manifested. BFlammer Syndrome^ (FS) phenotype may strongly contribute to particularly poor outcomes of metastatic breast cancer. Significance and relevance of individual FS symptoms for breast cancer metastatic disease are discussed in extenso.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EPMA Journal
ISSN
1878-5077
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
17
Pages from-to
141-157
UT code for WoS article
000405833600006
EID of the result in the Scopus database
2-s2.0-85020717512