Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10360779" target="_blank" >RIV/00216208:11140/17:10360779 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/17:10360779
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs12282-016-0716-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs12282-016-0716-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12282-016-0716-1" target="_blank" >10.1007/s12282-016-0716-1</a>

Result language
angličtina
Original language name
Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries
Original language description
Background Women diagnosed with breast cancer display higher propensity to develop second primary cancer in the contralateral breast (CBC). Identification of patients with increased risk of CBC and understanding relationships between hormone receptor (HR) statuses of the first and second breast cancers is desirable for endocrine-based prevention strategies. Methods Using 1992-2012 data from 13 SEER registries, the risk of developing CBC was determined as ratio of observed and expected second breast cancers (SIR). Association between HR statuses was examined by exploratory data analysis and multivariable logistic regression. Results: Women with ER-positive and ER-negative breast cancers have increased risk of developing CBC with SIR values 2.09 (CI 95 = 1.97-2.21) and 2.40 (CI 95 = 2.18-2.63), respectively. ER statuses of the CBC are moderately positively associated. In metachronous CBC, most cases with ER-positive first cancers had ER-positive second breast cancers (81.6 %; CI 95 = 80.2-82.9 %); however, considerable proportion of cases with ER-negative first cancers had ER-positive second cancers (48.8 %; CI 95 = 46.2-51.4 %). Conclusions Some women with ER-negative breast cancers may benefit from endocrine-based prevention of ER-positive CBC.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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