Nonsyndromic intestinal lipomas are probably not associated with mutations of PDGFRA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10360908" target="_blank" >RIV/00216208:11140/17:10360908 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/17:10360908

Result on the web

<a href="http://dx.doi.org/10.1097/PAI.0000000000000356" target="_blank" >http://dx.doi.org/10.1097/PAI.0000000000000356</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAI.0000000000000356" target="_blank" >10.1097/PAI.0000000000000356</a>

Result language

angličtina

Original language name

Nonsyndromic intestinal lipomas are probably not associated with mutations of PDGFRA

Original language description

The purpose of this study was to test the hypothesis that intestinal lipomas occurring in patients devoid of signs of PDGFRA-mutant syndrome might represent sporadic counterparts of familial lipomatous tumors occurring in the spectrum of tumors associated with PDGFRA mutations. PDGFRA-mutant syndrome may manifest with gastrointestinal stromal tumors, Vanek tumors, fibrous tumors, and lipomatous tumors. Until now there has been no molecular genetic study of PDGFRA mutations in intestinal lipomas published in the world literature. A series of 20 intestinal lipomas were obtained from 17 patients, and mutational analysis of exons 12, 14, and 18 of the PDGFRA gene was performed. None of the 16 analyzable tumors showed mutations in PDGFRA. Thus, PDGFRA mutations probably do not play an important role in the development of sporadic lipomas of the intestines.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30109 - Pathology

Project

<a href="/en/project/NT14227" target="_blank" >NT14227: Determining predictive factors for a therapeutic effect of chemotherapy in patients with stomach cancer</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Immunohistochemistry &amp; Molecular Morphology

ISSN

1541-2016

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

664-667

UT code for WoS article

000416660800014

EID of the result in the Scopus database

2-s2.0-84961226148