Spectrum of changes in anogenital mammary-like glands in primary extramammary (anogenital) Paget disease and their possible role in the pathogenesis of the disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10362203" target="_blank" >RIV/00216208:11140/17:10362203 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/PAS.0000000000000857" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000857</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000000857" target="_blank" >10.1097/PAS.0000000000000857</a>
Alternative languages
Result language
angličtina
Original language name
Spectrum of changes in anogenital mammary-like glands in primary extramammary (anogenital) Paget disease and their possible role in the pathogenesis of the disease
Original language description
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87.1%), usual ductal hyperplasia (22.6%), columnar cell hyperplasia (CCH) (9.7%), oxyphilic (apocrine) metaplasia (6.5%), and atypical duct hyperplasia (3.2%). Four cases (12.9%), in addition to intraepidermal carcinoma, harbored invasive carcinoma. In all 4 of these, AGMLG displayed a range of alterations including ductal carcinoma in situ, CCC, and CCH. Three further cases (9.7%) showed ductal carcinoma in situ without any definite invasive carcinoma. Colonization of AGMLG by neoplastic Paget ells was noted in 6 cases. As CCC and CCH may be encountered n normal AGMLG, these alterations are unlikely to play a ignificant role in the pathogenesis of the disease. However, by nalogy with mammary Paget disease, rare cases of primary EMPD ay originate in AGMLG with a subsequent upward migration of he neoplastic cells into the epidermis and possible later breach hrough the basal membrane. Usual ductal hyperplasia and atypical uct hyperplasia can then be regarded as earlier precursor lesions, inking both ends of the spectrum.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30216 - Dermatology and venereal diseases
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1053-1058
UT code for WoS article
000405558300006
EID of the result in the Scopus database
2-s2.0-85020714728