Cardiovascular Models: Heart Secondarily Affected by Disease (Diabetes Mellitus, Renal Failure, Dysfunctional Sympathetic Innervation)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10362381" target="_blank" >RIV/00216208:11140/17:10362381 - isvavai.cz</a>
Result on the web
<a href="https://www.elsevier.com/books/animal-models-for-the-study-of-human-disease/conn/978-0-12-809468-6" target="_blank" >https://www.elsevier.com/books/animal-models-for-the-study-of-human-disease/conn/978-0-12-809468-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-809468-6.00007-3" target="_blank" >10.1016/B978-0-12-809468-6.00007-3</a>
Alternative languages
Result language
angličtina
Original language name
Cardiovascular Models: Heart Secondarily Affected by Disease (Diabetes Mellitus, Renal Failure, Dysfunctional Sympathetic Innervation)
Original language description
Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e.g. electrophysiological, contractile remodeling) changes. The remodeling is initially compensatory and beneficial optimizing the pumping function but gradually it may become detrimental (heart failure, life-threatening arrhythmias). In this chapter we have focused on three experimental models, in which the heart is not targeted primarily, however the primary disease eventually affects the cardiovascular system significantly: diabetes mellitus, renal failure, and dysfunctional autonomic innervation. Rat models of these three conditions are described in detail with special focus on methodological aspects and experimental results obtained in our laboratory.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Animal Models for the Study of Human Disease
ISBN
978-0-12-809468-6
Number of pages of the result
29
Pages from-to
175-203
Number of pages of the book
1177
Publisher name
Elsevier
Place of publication
London
UT code for WoS chapter
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