MIC1/GDF15 as a Bone Metastatic Disease Biomarker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10365085" target="_blank" >RIV/00216208:11140/17:10365085 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/17:10365085

Result on the web

<a href="http://dx.doi.org/10.21873/anticanres.11477" target="_blank" >http://dx.doi.org/10.21873/anticanres.11477</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.11477" target="_blank" >10.21873/anticanres.11477</a>

Result language

angličtina

Original language name

MIC1/GDF15 as a Bone Metastatic Disease Biomarker

Original language description

Aim: The aim of the study was to evaluate MIC1/GDF15 as a biomarker in the monitoring of bone metastases occurrence. Patients and Methods: The assessed group included patients diagnosed with: prostate cancer, breast cancer, lung cancer and colorectal cancer. Patients were divided into two groups based on the scintigraphy of the occurrence of bone metastases. Group 0 contained 55 patients without bone metastases, that served as the control group. Group 1 contained 75 patients with bone metastases. Results: Higher levels ( p&lt;0.0001) of MIC1/GDF15 were found in group 1 (with bone metastases) compared to the group 0. Receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) 0.87. At the point of 90% specificity we found a 65% sensitivity and cut-off value of 1.48 ng/ml. Conclusion: Circulating MIC1/GDF15 is a powerful biomarker for bone metastatic disease but insufficient sensitivity calls for further studies incorporating combinations with other novel or routine markers.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NT13655" target="_blank" >NT13655: Biomarkers of Bone Metastatic Disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

5

Pages from-to

1501-1505

UT code for WoS article

000397129600074

EID of the result in the Scopus database

2-s2.0-85015820095