Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10366464" target="_blank" >RIV/00216208:11140/17:10366464 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/17:10366464

Result on the web

<a href="http://dx.doi.org/10.21873/anticanres.12161" target="_blank" >http://dx.doi.org/10.21873/anticanres.12161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12161" target="_blank" >10.21873/anticanres.12161</a>

Result language

angličtina

Original language name

Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer

Original language description

Background/Aim: To date, many studies have suggested that thymidylate synthase (TS) could be used as a prognostic and predictive marker in non-small cell lung cancer (NSCLC) patients. However, results have been contradictory. The aim of this study was to evaluate TS mRNA levels in tumor tissue of NSCLC patients who underwent complete surgical resection and to analyze its prognostic and predictive potential. Materials and Methods: The study group consisted of 64 patients who underwent curative lung resection. Paired lung tissue samples were taken directly from the tumor tissue and from adjacent, histologically cancer-free lung tissue. The quantitative estimation of TS expression was performed by reverse transcription real-time polymerase chain reaction (RT-qPCR). The relationship between TS expression level and disease-free interval (DFI) and overall survival (OS) was analyzed. Results: There was significantly higher TS expression in NSCLC tumor tissue comparing to normal lung tissue. In the group of patients who received adjuvant chemotherapy based on platinum derivatives in combination with paclitaxel or gemcitabine, we found shorter DFI (p= 0.0473) and OS (p= 0.0053) in those with high expression of TS. Conclusion: Our results demonstrated the relationship of high tumor tissue TS levels to adverse prognosis in patients undergoing adjuvant chemotherapy. TS is a non-specific tumor marker with respect to NSCLC, therefore we think that its best use would be as a member of the panel of predictors of adjuvant treatment efficacy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

12

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

6953-6958

UT code for WoS article

000417022100056

EID of the result in the Scopus database

2-s2.0-85038130110