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Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10365342" target="_blank" >RIV/00216208:11140/18:10365342 - isvavai.cz</a>

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1002/uog.18955/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/uog.18955/epdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/uog.18955" target="_blank" >10.1002/uog.18955</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval

  • Original language description

    Objectives: To analyse the oocyte competence in GnRHa stimulation cycles with regard to maturity, fertilization and blastocyst rate and clinical outcome (pregnancy and live birth rate) in correlation to follicular volume measured by 3D sonography and follicular fluid composition. Methods: This was a prospective single-centre study conducted in the period June 2012 - June 2014 including 118 ovum pick-ups (OPUs) with subsequent embryo transfers (ET). Out of 1,493 aspirated follicles we analysed 1,236 follicles and traced oocytes grouped according to follicular volume. Follicular volumes were evaluated using 3D ultrasound during oocyte retrieval. Oocyte maturity and blastocyst development was tracked according to follicular volume. Ovarian stimulation was performed using the GnRHa long protocol. Intrafollicular concentrations of estradiol (E2), testosterone (T), progesterone (P), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and granulocyte-colony stimulating factor (G-CSF) were quantified by immunoassay. Clinical outcome in terms of implantation rate (IR), (clinical) pregnancy rate (PR), miscarriage and live birth rate (LBR) was evaluated. Results: Although MII oocyte recovery rate was significantly lower for small follicles compared to larger ones (8-12mm/0.3-0.9mL: 63.8% vs. 13-23mm/1-6mL: 76.6% and GREATER-THAN OR EQUAL TO 24mm/GREATER-THAN OR EQUAL TO6mL: 81.3%; P-value &lt; 0.001), similar fertilization rates (FR; 85.1%;75.8% and 81.4%; n.s.) and blastocyst rates per mature MII oocytes (40.5%, 40.6% and 37.2%, respectively; n.s.) were observed. A trend towards higher LBR after transfer of blastocysts erived from small follicles &lt;1mL compared to follicles 1-6mL or &gt;6mL was observed (LBR: 54.5%, 42.0%, and 41.7%, respectively; n.s.). No predictive value of follicular fluid (FF) biomarkers was found. Conclusions: Our data indicate that the optimal follicular volume for a high yield of good quality blastocysts with good potential to lead to a live birth is between 13- 23mm/1-6mL. However, oocytes derived from small follicles 8-12mm/0.3-0.9mL still have the capacity for normal development and subsequent delivery of healthy children, suggesting that aspiration of these follicles increases the number of blastocysts per stimulation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10307 - Acoustics

Result continuities

  • Project

    <a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Ultrasound in Obstetrics and Gynecology

  • ISSN

    0960-7692

  • e-ISSN

  • Volume of the periodical

    51

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    118-125

  • UT code for WoS article

    000428231900015

  • EID of the result in the Scopus database

    2-s2.0-85040132871