Decitabine improves response rate and prolongs progression-free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO-016 trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10374377" target="_blank" >RIV/00216208:11140/18:10374377 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10374377
Result on the web
<a href="https://doi.org/10.1002/ajh.25062" target="_blank" >https://doi.org/10.1002/ajh.25062</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.25062" target="_blank" >10.1002/ajh.25062</a>
Alternative languages
Result language
angličtina
Original language name
Decitabine improves response rate and prolongs progression-free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO-016 trial
Original language description
Decitabine improved response rates and PFS compared with other standard therapies for patients who were ineligible for intensive chemotherapy, with a benefit of almost 4 months in median OS. Although the prognosis in MK AML is usually particularly poor, the median OS in decitabine-treated MK AML patients in the present analysis was comparable to that among MK- patients with unfavorable cytogenetics. This suggests a potential positive effect of decitabine in patients with MK AML, possibly by reactivating haplo-insufficient tumor suppressor gene mapping on monosomal autosomes.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
—
Volume of the periodical
93
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
"E125"-"E127"
UT code for WoS article
000429537600007
EID of the result in the Scopus database
2-s2.0-85042398067