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Decitabine improves response rate and prolongs progression-free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO-016 trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10374377" target="_blank" >RIV/00216208:11140/18:10374377 - isvavai.cz</a>

  • Alternative codes found

    RIV/00669806:_____/18:10374377

  • Result on the web

    <a href="https://doi.org/10.1002/ajh.25062" target="_blank" >https://doi.org/10.1002/ajh.25062</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ajh.25062" target="_blank" >10.1002/ajh.25062</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Decitabine improves response rate and prolongs progression-free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO-016 trial

  • Original language description

    Decitabine improved response rates and PFS compared with other standard therapies for patients who were ineligible for intensive chemotherapy, with a benefit of almost 4 months in median OS. Although the prognosis in MK AML is usually particularly poor, the median OS in decitabine-treated MK AML patients in the present analysis was comparable to that among MK- patients with unfavorable cytogenetics. This suggests a potential positive effect of decitabine in patients with MK AML, possibly by reactivating haplo-insufficient tumor suppressor gene mapping on monosomal autosomes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    American Journal of Hematology

  • ISSN

    0361-8609

  • e-ISSN

  • Volume of the periodical

    93

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    3

  • Pages from-to

    "E125"-"E127"

  • UT code for WoS article

    000429537600007

  • EID of the result in the Scopus database

    2-s2.0-85042398067