Long-term development of embryonic cerebellar grafts in two strains of lurcher mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10375041" target="_blank" >RIV/00216208:11140/18:10375041 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs12311-018-0928-3" target="_blank" >https://link.springer.com/article/10.1007%2Fs12311-018-0928-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12311-018-0928-3" target="_blank" >10.1007/s12311-018-0928-3</a>

Result language

angličtina

Original language name

Long-term development of embryonic cerebellar grafts in two strains of lurcher mice

Original language description

For many degenerative cerebellar diseases, currently no effective treatment that would substantially restore cerebellar functions is available. Neurotransplantation could be a promising therapy for such cases. Nevertheless, there are still severe limitations for routine clinical use. The aim of the work was to assess volume and morphology and functional impact on motor skills of an embryonic cerebellar graft injected in the form of cell suspension in Lurcher mutant and wild type mice of the B6CBA and C3H strains after a 6-month survival period. The grafts survived in the majority of the mice. In both B6CBA and C3H Lurcher mice, most of the grafts were strictly delimited with no tendency to invade the host cerebellum, while in wild type mice graft-derived Purkinje cells colonized the host&apos;s cerebellum. In C3H Lurcher mice, but not in B6CBA Lurchers, the grafts had smaller volume than in their wild type counterparts. C3H wild type mice had significantly larger grafts than B6CBA wild type mice. No positive effect of the transplantation on performance in the rotarod test was observed. The findings suggest that the niche of the Lurcher mutant cerebellum has a negative impact on integration of grafted cells. This factor seems to be limiting for specific functional effects of the transplantation therapy in this mouse model of cerebellar degeneration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Cerebellum

ISSN

1473-4222

e-ISSN

—

Volume of the periodical

17

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

428-437

UT code for WoS article

000437113000005

EID of the result in the Scopus database

2-s2.0-85042099001