Follicular fluid levels of anti-Mullerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10375960" target="_blank" >RIV/00216208:11140/18:10375960 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/18:10375960

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/19396368.2018.1450906" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/19396368.2018.1450906</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/19396368.2018.1450906" target="_blank" >10.1080/19396368.2018.1450906</a>

Result language

angličtina

Original language name

Follicular fluid levels of anti-Mullerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders

Original language description

Anti-Mullerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology.Abbreviations: AMH: anti-Mullerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Systems biology in reproductive medicine

ISSN

1939-6368

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

220-223

UT code for WoS article

000432658800009

EID of the result in the Scopus database

2-s2.0-85044516410