Perfusion of a Kidney Graft From a Donor After Cardiac Death Based on Immediately Started Pulsatile Machine Perfusion-An Experimental Study on a Small Animal

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10376169" target="_blank" >RIV/00216208:11140/18:10376169 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/18:00321916 RIV/00669806:_____/18:10376169

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0041134518302185" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0041134518302185</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2018.02.067" target="_blank" >10.1016/j.transproceed.2018.02.067</a>

Result language

angličtina

Original language name

Perfusion of a Kidney Graft From a Donor After Cardiac Death Based on Immediately Started Pulsatile Machine Perfusion-An Experimental Study on a Small Animal

Original language description

Introduction There is still a lack of organs for kidney transplantation. The aim of our experimental animal study was to improve the quality of the kidney grafts from donors after cardiac death (DCD) using immediate start of machine perfusion instead of perfusion based on hydrostatic pressure. Methods Ten rabbits were used as an experimental model. In group A, 5 kidneys after ischemic injury were perfused in situ using hydrostatic pressure. In group B, 5 kidneys were perfused in situ using machine pulsatile perfusion. After nephrectomy kidney parenchyma was histologically analyzed. We have evaluated the maximum perfusion flow rate, temperature drop rate, and degree of parenchymal injury. Results The flow rate in the group of machine-perfused animals (group B) was significantly higher than in the control group (group A), and temperature was significantly decreased in group B (P &lt; .001). Qualitative histopathologic evaluation of the perfusion quality of the grafts was statistically significant, again in favor of machine perfusion in group B (P = .005). Discussion According to our results, the immediate start of machine perfusion is a superior method of kidney graft preservation in DCDs. All observed modalities were superior in the group with machine perfusion compared with usual clinical practice.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

—

Volume of the periodical

50

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

1544-1548

UT code for WoS article

000441211400055

EID of the result in the Scopus database

2-s2.0-85047869903