Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10376629" target="_blank" >RIV/00216208:11140/18:10376629 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10376629
Result on the web
<a href="https://insights.ovid.com/pubmed?pmid=29112060" target="_blank" >https://insights.ovid.com/pubmed?pmid=29112060</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/QAD.0000000000001684" target="_blank" >10.1097/QAD.0000000000001684</a>
Alternative languages
Result language
angličtina
Original language name
Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?
Original language description
Objective:The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown.Method:EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4(+) cell count 350/l, viral load 10000 copies/ml), low risk (CD4(+) cell count 500 cells/l, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events.Results:A total of 16839 persons were included with 136688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-to-three-fold increase in older persons (P=0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-to-four-fold difference in all other regions (P=0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P<0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P=0.57, 0.060 and 0.090, respectively, interaction).Conclusion:Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AIDS
ISSN
0269-9370
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
205-215
UT code for WoS article
000418864000008
EID of the result in the Scopus database
2-s2.0-85039718151