Tumor-related Perfusion Changes in White Matter Adjacent to Brain Tumors: Pharmacodynamic Analysis of Dynamic 3T Magnetic Resonance Imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10376777" target="_blank" >RIV/00216208:11140/18:10376777 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/18:10376777

Result on the web

<a href="https://doi.org/10.21873/anticanres.12707" target="_blank" >https://doi.org/10.21873/anticanres.12707</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12707" target="_blank" >10.21873/anticanres.12707</a>

Result language

angličtina

Original language name

Tumor-related Perfusion Changes in White Matter Adjacent to Brain Tumors: Pharmacodynamic Analysis of Dynamic 3T Magnetic Resonance Imaging

Original language description

BACKGROUND/AIM: To verify perfusion differences in white matter adjacent to glioblastomas and metastatic tumors in dynamic contrast-enhanced (DCE) 3T-magnetic resonance imaging (MRI) using gradient echo (GRE) T1 techniques. MATERIALS AND METHODS: A retrospective comparative study was carried out on adults with glioblastoma (n=67) and brain metastases (n=31). In each patient, conventional 3T-MRI and DCE-MRI with 25 acquisitions of GRE-T1 were performed. The initial area under the contrast-uptake curve (iAUC) and transfer constant (K trans ) in peritumoral regions of the white matter were evaluated using T1 pharmacodynamic modeling software. RESULTS: Statistically significantly higher relative iAUC (p&lt;0.001) and K trans (p&lt;0.01) values were recorded for peritumoral white matter near glioblastomas compared to that near metastases: 2.29 (SD=1.11) and 2.12 (SD=1.05) vs. 0.96 (SD=0.31) and 1.18 (SD=0.35), respectively. CONCLUSION: In comparison to K trans , the iAUC obtained by DCE-MRI is more suitable for assessing glioblastomas because it better reflects pharmacokinetic peritumoral changes. Increased iAUC in white matter near to tumor generally indicates glioblastoma, however, a low level does not exclude it. Copyright(C) 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

7

Country of publishing house

GR - GREECE

Number of pages

4

Pages from-to

4149-4152

UT code for WoS article

000449943500046

EID of the result in the Scopus database

2-s2.0-85049780918