Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10381187" target="_blank" >RIV/00216208:11140/18:10381187 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10381187
Result on the web
<a href="https://doi.org/10.1136/heartjnl-2017-312569" target="_blank" >https://doi.org/10.1136/heartjnl-2017-312569</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/heartjnl-2017-312569" target="_blank" >10.1136/heartjnl-2017-312569</a>
Alternative languages
Result language
angličtina
Original language name
Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
Original language description
Objectives Determinants of atrial fibrillation (AF) patterns and of progression of earlier forms to permanent AF, and their relationship with outcome are still poorly understood. Methods We examined AF patterns (paroxysmal, persistent and permanent), rate and predictors of AF progression, and outcomes in the PREFER (PREvention oF thromboembolic events-European Registry) in AF. The primary analysis was performed in the PREFER in AF prolongation dataset (n=3223patients with AF with a complete 1-year follow-up, mean age 729 years, 40% women). Sensitivity analyses were performed using the PREFER in the AF study (n=6390 patients). Results AF progressed to more persistent types in 506 patients (17%). Permanent AF was associated with development of heart failure at 1year (OR 1.80, 95% CI 1.06 to 3.07, p=0.03) compared with paroxysmal AF, which was confirmed in the entire cohort. In multivariable-adjusted models, sinus rhythm at baseline, AF duration, cardioversion, hyperthyroidism, valvular heart disease, diabetes mellitus and heart failure were predictors of AF progression (area under the receiver operating characteristic curve 0.60, 95%CI 0.57 to 0.63). Results were similar when we restricted analyses to patients with AF duration <1year. AF progression showed an association with coronary events over 1year (OR 2.27, 95%CI 1.22 to 4.19, p=0.0074). Conclusions Permanent AF at baseline was associated with incident heart failure. A substantial proportion of well-managed patients with AF showed AF progression over 1year. AF progression itself was not strongly related to outcome and may indicate the need to refine the current classification of AF types to enhance clinical utility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Heart
ISSN
1355-6037
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1608-1614
UT code for WoS article
000446083900012
EID of the result in the Scopus database
2-s2.0-85049139655