Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an efeective screening tool in identifying uterine ALK-rearranged mesenchymal tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10381711" target="_blank" >RIV/00216208:11140/18:10381711 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10381711
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007%2Fs00428-018-2428-8.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007%2Fs00428-018-2428-8.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-018-2428-8" target="_blank" >10.1007/s00428-018-2428-8</a>
Alternative languages
Result language
angličtina
Original language name
Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an efeective screening tool in identifying uterine ALK-rearranged mesenchymal tumors
Original language description
We examined the value of targeted molecular screening for the identification of uterine anaplastic lymphoma kinase (ALK)-rearranged mesenchymal tumors, including ALK immunohistochemistry followed by molecular genetic testing, in all uterine leiomyosarcomas and STUMPs (smooth muscle tumors of uncertain malignant potential). All leiomyosarcoma and STUMP cases diagnosed in a 10-year period (2006-2016) at Charles University Faculty of Medicine in Pilsen were retrieved and reviewed. Of 23 cases, one case (LMS [leiomyosarcoma]) was positive for ALK rearrangement, namely, PPP1CB-ALK fusion gene. No specific histologic features (i.e., lymphocytic infiltrate and stromal edema) were observed in this case. This suggests that inflammatory myofibroblastic tumor (IMT)-like histologic features may not be an initial reliable screening tool in identifying uterine IMT cases. Thus, we proposed a two-step IHC and molecular genetic testing (as a reflex test) for IMT in all uterine LMS and STUMP cases. This will enhance the proper detection of such tumors at the population level and ultimately offer patients available targeted therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virchows Archiv
ISSN
0945-6317
e-ISSN
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Volume of the periodical
473
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
583-590
UT code for WoS article
000448861800006
EID of the result in the Scopus database
2-s2.0-85052120925