Single-source Dual-energy CT as a Part of F-18-FDG PET/CT: Direct Comparison of Iodine-related and Metabolic Parameters in Non-small Cell Lung Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10384200" target="_blank" >RIV/00216208:11140/18:10384200 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/18:10384200

Result on the web

<a href="https://doi.org/10.21873/anticanres.12704" target="_blank" >https://doi.org/10.21873/anticanres.12704</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12704" target="_blank" >10.21873/anticanres.12704</a>

Result language

angličtina

Original language name

Single-source Dual-energy CT as a Part of F-18-FDG PET/CT: Direct Comparison of Iodine-related and Metabolic Parameters in Non-small Cell Lung Cancer

Original language description

Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materials and Methods: Forty-eight patients with histologically-proven NSCLC underwent F-18-FDG-PET/CT within their staging process. PET/CT included single-source DE-CT in late post-contrast phase. Direct comparison of PET and DE-related values was performed. A sub-study regarding different histological types and various thresholds for quantification of volume metabolic values was also performed. Results: A strong correlation was found of metabolic tumor volume and total lesion glycolysis with total iodine content using Pearson correlation analysis (r=0.965-0.983; p&lt;0.0001) with various thresholds for FDG lesion segmentation. The strongest correlations with iodine content were reached using 10% threshold for segmentation. Only a weak correlation was found between iodine content and the maximal standard uptake value. A significant difference between adenocarcinomas and other histological subtypes was found for selected parameters of metabolic PET and DE-CT data. Conclusion: Our study demonstrated a strong correlation of the iodine content calculated from single-source DE-CT with volumetric FDG parameters in NSCLC. without a significant effect of the threshold value for FDG lesion segmentation.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NV17-30748A" target="_blank" >NV17-30748A: A new approach by combination of functional imaging and tumor genomics for non-invasive phenotyping and monitoring of therapy of lung carcinomas</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

7

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

4131-4137

UT code for WoS article

000449943500043

EID of the result in the Scopus database

2-s2.0-85049775947