Endothelial dysfunction in children and young adults: A combined diagnostic approach of plethysmographic and biochemical markers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10384952" target="_blank" >RIV/00216208:11140/18:10384952 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10384952
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Endothelial dysfunction in children and young adults: A combined diagnostic approach of plethysmographic and biochemical markers
Original language description
We provide current, normative data on a new examination method of endothelial dysfunction (ED) in childhood. The reversibility of ED is anattractive primary target in the effort to decrease cardiovascular risk in pediatric patients and to optimize therapeutic strategies. Thus, early detection of ED may have therapeutic and prognostic implications. Novel non-invasive diagnostic tools ensuring the capture of ED are needed. One of them is the combined diagnostic approach of plethysmographic and laboratory methods that our current research concentrates on. The objective of our prospective study was to evaluate endothelial dysfunction especially in children with chronic diseases using a combination of plethysmographic reactive hyperemia index (RHI) and specific biomarkers - plasma concentrations of assymetric dimethylarginine (ADMA), high-sensitive C-reactive protein (hsCRP), E-selectine and vasoadhesive molecules (VCAM) in comparison with the healthy controls. RHI was further correlated with anthropometric and biochemical parameters. Significantly decreased RHI with elevated plasma concentrations of biochemical markers implies a possible association with premature ED in patients with chronic diseases. The combined diagnostic approach seems to be a valuable tool for more accurate detection of ED and preventive cardiovascular management in these patients [1]. (C) 2018 Nova Science Publishers, Inc. All rights reserved.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Advances in Health and Disease
ISBN
978-1-5361-3951-8
Number of pages of the result
14
Pages from-to
189-202
Number of pages of the book
273
Publisher name
Nova Science Publishers, Inc.
Place of publication
New York
UT code for WoS chapter
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