Hybrid Imaging PET/CT with Application of F-18-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10386449" target="_blank" >RIV/00216208:11140/18:10386449 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10386449
Result on the web
<a href="https://doi.org/10.21873/anticanres.12708" target="_blank" >https://doi.org/10.21873/anticanres.12708</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.12708" target="_blank" >10.21873/anticanres.12708</a>

Result language
angličtina
Original language name
Hybrid Imaging PET/CT with Application of F-18-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy
Original language description
Aim: To introduce the possible benefits of the positron-emission tomography (PET)Icomputed tomography (CT) with F-18-3'-deoxy-3'-fluorothymidine ( F-18-FLT) in patients with orofacial carcinomas and its impact to patient management. Materials and Methods: Thirty-six patients with orofacial squamous cell carcinomas underwent F-18-FLT-PET/CT during radiotherapy. Examinations were performed after administration of F-18-FLT (1.8 MBq/kg) including full-diagnostic CT. Analysis of the radiotherapy effect was performed with possible prospect of repeated and focused irradiation. Results: Complete absence of F-18-FLT uptake was found in 20 patients, thus complete response to radiotherapy was reported. Persistence of focal F-18-FLT uptake was observed in 16 patients; in 11 patients, the measured activity was only mild. In five patients, a higher level of F-18-FLT uptake was measured and additional irradiation was performed in defined regions. Repeated follow-up proved complete regression F-18-FLT uptake. Conclusion: It was possible to assess the effect of radiotherapy with the use of F-18-FLT-PET/CT and findings are suitable for radiation dose-escalation planning.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)