"Fat-rich" (Spindle Cell-poor) Variants of Atypical Spindle Cell Lipomatous Tumors Show Similar Morphologic, Immunohistochemical and Molecular Features as "Dysplastic Lipomas" Are They Related Lesions?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10395314" target="_blank" >RIV/00216208:11140/19:10395314 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ylM74Oj1rS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ylM74Oj1rS</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000001184" target="_blank" >10.1097/PAS.0000000000001184</a>
Alternative languages
Result language
angličtina
Original language name
"Fat-rich" (Spindle Cell-poor) Variants of Atypical Spindle Cell Lipomatous Tumors Show Similar Morphologic, Immunohistochemical and Molecular Features as "Dysplastic Lipomas" Are They Related Lesions?
Original language description
We appreciated the interest of Dr Creytens et al in our recent publication on dysplastic lipoma.1 This tumor has: (1) a very strong male predominance, (2) a predilection for the posterior neck, upper back and shoulder regions, (3) multifocality in TILDE OPERATOR+D9119% of patients, (4) a rare association with retinoblastoma, and (5) mildly increased risk (currently estimated at around 10%) for local recurrence with simple excision, as compared with a conventional lipoma. To date, all examples have been subcutaneous, though some examples have occurred in locations were tissue planes are somewhat ambiguous (eg, the lateral/anterior neck and groin regions). The key histologic features are: (1) notable adipocytic size variation, (2) patchy (typically single cell) fat necrosis, and (3) focal adipocytic nuclear atypia. The atypical adipocytes may be mononucleated or multinucleated. The atypia is generally mild and can be quite subtle, but in some instances, it is more pronounced and similar to that seen in a conventional atypical lipomatous tumor. Immunohistochemical expression for p53 is always present, but it is limited to a subpopulation of the adipocytes, typically those with the greatest atypia. MDM2 immunoexpression can be present, but it is almost invariably less prominent than the p53 immunoexpression, and FISH analysis for MDM2 gene amplification is always negative.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
289-290
UT code for WoS article
000458401800018
EID of the result in the Scopus database
2-s2.0-85056725042