STRN-NTRK3-rearranged Mesenchymal Tumor of the Uterus Expanding the Morphologic Spectrum of Tumors With NTRK Fusions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10399642" target="_blank" >RIV/00216208:11140/19:10399642 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=azbSFx_9ls" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=azbSFx_9ls</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000001292" target="_blank" >10.1097/PAS.0000000000001292</a>
Alternative languages
Result language
angličtina
Original language name
STRN-NTRK3-rearranged Mesenchymal Tumor of the Uterus Expanding the Morphologic Spectrum of Tumors With NTRK Fusions
Original language description
We have followed with great interest several recent reports published mainly in this journal on NTRK-rearranged mesenchymal tumors. The largest series by Davis and colleagues focused on NTRK-rearranged pediatric mesenchymal tumors. Although the studied tumors showed certain variation in histologic appearances, all lesions manifested patterns previously reported in infantile fibrosarcoma.1 Tumors with lipofibromatosis-like morphology and S100-protein and CD34 co-expression harboring NTRK1 fusions were reported by Agaram et al,2 and potentially related tumors with NTRK1/2 fusions by Suurmeijer et al.3 In 2 other publications, very similar tumors with fibrosarcoma-like morphology were presented. In the first one, a soft tissue tumor with STRN3 (exon 3)-NTRK3 (exon 14) fusion along with a bone tumor harboring STRN (exon 3)-NTRK3 (exon 14) rearrangement was described. Both cases showed diffuse pan-TRK and CD34 immunostaining, whereas S100 protein was negative.4 In the second article, 4 additional cases with RBPMS-NTRK3 and various NTRK1 fusions were reported. Apart from diffuse pan-TRK positivity, the neoplasms showed focal S100 protein expression but were negative for CD34 staining. Of note, the tumors involved the uterine cervix (n=3) and corpus (n=1) and were thus the first NTRK-rearranged tumors ever reported in this location.5
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30109 - Pathology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
—
Volume of the periodical
43
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1152-1154
UT code for WoS article
000479116500017
EID of the result in the Scopus database
2-s2.0-85069888486