Heparin-induced thrombocytopenia treated with fondaparinux: single centre experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10403517" target="_blank" >RIV/00216208:11140/20:10403517 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/20:10403517 RIV/00179906:_____/20:10403517 RIV/00669806:_____/20:10403517
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Li0lVxyNU9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Li0lVxyNU9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23736/S0392-9590.19.04247-0" target="_blank" >10.23736/S0392-9590.19.04247-0</a>
Alternative languages
Result language
angličtina
Original language name
Heparin-induced thrombocytopenia treated with fondaparinux: single centre experience
Original language description
BACKGROUND:Heparin-induced thrombocytopenia (HIT) is the most frequent drug- induced, immune-mediated thrombocytopenia. It is associated with significant morbidity and mortality. Anticoagulation with heparin must be stopped immediately and replaced by some suggested alternative - lepirudin, danaparoid or argatroban. Fondaparinux has been also successfully used in HIT.METHODS:We present a cohort of 10 patients diagnosed with HIT and treated in a university hospital in a period of four years. Diagnosis was based on Keeling s scoring system, screening imunologic test for HIT (STic EXPERT(R) HIT) and sandwich ELISA (detection of IgG/ heparin-PF4 antibodies). While other alternative anticoagulants are not readily available in our hospital, we used fondaparinux in all cases.RESULTS:From 2014 to 2018, eight males and two females (mean age 67 years, range 46-86 years) were diagnosed with HIT in our hospital. This complication developed in 9 cases after low-molecular-weight heparin and in one after heparin flushes in hemodialysis. A drop in platelet count developed in all patients, thrombotic complications in 7 and skin necrosis in 2 cases. Fondaparinux was used in all patients, including two cases with severe renal impairment, the dose was chosen individually. We observed complete platelet recovery in all cases. One patient died because of advanced malignancy, others did not have any complication. In 6 cases we switched to oral anticoagulation after platelet recovery.CONCLUSIONS:In our group of 10 HIT patients fondaparinux was shown to be both safe and effective, even in those with severe renal impairment. Additional studies are warranted to confirm this observation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Angiology
ISSN
0392-9590
e-ISSN
—
Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
IT - ITALY
Number of pages
6
Pages from-to
76-81
UT code for WoS article
000550122800009
EID of the result in the Scopus database
2-s2.0-85081094215