Is PIVKA-II a Promising Biomarker for Hepatocellular Carcinoma?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10410976" target="_blank" >RIV/00216208:11140/20:10410976 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/20:10410976
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gFjC6EEako" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gFjC6EEako</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Is PIVKA-II a Promising Biomarker for Hepatocellular Carcinoma?
Original language description
Aim. To evaluate the clinical contribution of protein induced by vitamin K absence (PIVKA-II) for the diagnosis of hepatocellular carcinoma (HCC). The second aim was to compare PIVKA-II with routinely used alpha-fetoprotein (AFP) for the same indication. Materials and methods. 310 participants were enrolled in our study: 60 with HCC, 40 with liver metastases of colorectal cancer origin, 40 with liver cirrhosis, 20 with pancreatic cancer (PC) and 150 healthy individuals. Serum levels of PIVKA-II were measured using a chemiluminescent assay of the Architect 1000i System ("Abbott", USA) and AFP levels using a chemiluminescent assay by DxI 800 ("Beckman Coulter", USA). Serum concentrations of PIVKA-II and AFP were compared between the group with HCC and the other mentioned groups. Results. PIVKA-II achieved better clinical sensitivity in comparison with AFP. PIVKA-II achieved its best sensitivity (96,9 %) in distinguishing between the HCC and control group with the proposed cut-off value of 60 mAU/ml. Conclusion. PIVKA-II can be used alongside routinely established AFP as a valuable marker in the diagnosis of HCC.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Astrachanskij medicinskij žurnal
ISSN
1992-6499
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
RU - RUSSIAN FEDERATION
Number of pages
4
Pages from-to
6-9
UT code for WoS article
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EID of the result in the Scopus database
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