The newly proposed international endocervical adenocarcinoma criteria and classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10413022" target="_blank" >RIV/00216208:11140/20:10413022 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/20:W0000019 RIV/00669806:_____/20:10413022
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OVswsb0v9Z" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OVswsb0v9Z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cyt.12831" target="_blank" >10.1111/cyt.12831</a>
Alternative languages
Result language
angličtina
Original language name
The newly proposed international endocervical adenocarcinoma criteria and classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases
Original language description
Background: It is generally acknowledged that interobserver variability for the histological diagnosis of endocervical adenocarcinoma (EA) subtypes is suboptimal. The recently proposed International Endocervical Adenocarcinoma Criteria and Classification (IECC) system is based on the presence of associated human papilloma virus (HPV) infection. It recognises HPV-associated EAs and non-HPV-associated EAs. Methods: This prospective cytology-histology and molecular genetics-based study investigated the potential effect of IECC being applied to Papanicolaou (Pap) test with regard to the diagnostic accuracy of severe glandular lesions reported at least as adenocarcinoma in situ (AIS). Results: Out of 118 liquid-based cytology Pap tests with AIS+ lesion, complete information on follow-up biopsy and HPV status was available in 51 cases. AIS and EA category correlated with histologically confirmed AIS/EA in 88.5% (23/26) and 70.5% (12/17) of cases, respectively. Interestingly, 93% (40/43) of cases diagnosed as AIS/EA were HPV positive and 7% (3/43) were HPV negative (originating in the cervix, endometrium and adnexa). Conclusions: Our findings suggest that this approach could possibly divide Pap tests containing severe glandular lesion into two groups: (a) robust diagnosis of HPV-associated EA and (b) non-HPV associated glandular lesions of heterogeneous origin, requiring further clinical preoperative diagnostic workup.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytopathology
ISSN
0956-5507
e-ISSN
—
Volume of the periodical
31
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
288-291
UT code for WoS article
000550484500004
EID of the result in the Scopus database
2-s2.0-85086412373