Gene fusion characteristion of rare aggressive prostate cancer variants - adenosquamous carcinoma, pleomorphic giant-cell carcinoma, and sarcomatoid carcinoma: an analysis of 19 cases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10419998" target="_blank" >RIV/00216208:11140/20:10419998 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5eS1bPdKF9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5eS1bPdKF9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/his.14205" target="_blank" >10.1111/his.14205</a>
Alternative languages
Result language
angličtina
Original language name
Gene fusion characteristion of rare aggressive prostate cancer variants - adenosquamous carcinoma, pleomorphic giant-cell carcinoma, and sarcomatoid carcinoma: an analysis of 19 cases
Original language description
The overwhelming majority of prostate cancers are conventional acinar adenocarcinomas. Although architectural and cytological variants are common such as atrophic, pseudohyperplastic or foamy gland variants, unusual histological variants such as adenosquamous carcinoma, sarcomatoid carcinoma and pleomorphic giant-cell carcinoma are exceedingly rare and are known to behave aggressively.1,2 Approximately half of adenosquamous and sarcomatoid carcinomas have been reported in the setting of previous treatment for conventional prostatic adenocarcinoma, suggesting evolution from the conventional carcinoma component.3 However, our understanding of the molecular characteristics o these rare variants is currently limited. To our knowledge, only a few studies assessing a handful of cases have examined the molecular characteristics of these rare variants.4-7 A better understanding of the molecular features of these tumour variants could shed light on the clinical and biological diversity of prostate cancer, and potentially have therapeutic significance. We studied a cohort of rare prostati carcinoma variants, including adenosquamous carcinoma, sarcomatoid carcinoma, and pleomorphic giant-cell carcinoma, for their molecular profiles, using fluorescence in-situ hybridisation (FISH) and next-generation sequencing (NGS).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histopathology
ISSN
0309-0167
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
890-899
UT code for WoS article
000569358400001
EID of the result in the Scopus database
2-s2.0-85090971055