The Role of Cell Blocks and Immunohistochemistry in Thyroid Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Bethesda Category

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10426104" target="_blank" >RIV/00216208:11140/21:10426104 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10426104 RIV/00064203:_____/21:10426104

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FpEkfVwcY6" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FpEkfVwcY6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000514906" target="_blank" >10.1159/000514906</a>

Result language

angličtina

Original language name

The Role of Cell Blocks and Immunohistochemistry in Thyroid Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Bethesda Category

Original language description

INTRODUCTION: Thyroid cytology is a widely accepted tool in the clinical triaging of nodular lesions. Cell blocks (CBs) can help in the diagnosis of atypical lesions, namely, thyroid Bethesda category of Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). METHODS: In a series of 224 AUS/FLUS thyroid samples with CB, we studied CB cellularity and feasibility of 3 immunohistochemical markers (cytokeratin 19 [CK19], HBME-1, and galectin-3) apart and in combination. RESULTS: The CBs were non-diagnostic in 34 cases. Twenty-four CBs contained &lt;10 cells, 45 CBs 10-50 cells, and 121 CBs &gt;50 cells. Notably, more cellularity was found in CBs performed by plasma-thrombin and in-house techniques (p &lt; 0.001). The diagnostic accuracy to detect malignancy was 65.1% for CK19, 72.1% for HBME-1, and 70.3% for galectin-3. CONCLUSION: In conclusion, CB cellularity is essential for successful immunohistochemistry application and further diagnostic workup of AUS/FLUS cases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30206 - Otorhinolaryngology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Cytologica

ISSN

0001-5547

e-ISSN

—

Volume of the periodical

65

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

257-263

UT code for WoS article

000635745400001

EID of the result in the Scopus database

2-s2.0-85103535583