Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10429973" target="_blank" >RIV/00216208:11140/21:10429973 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921841 RIV/75010330:_____/21:00013525 RIV/00064173:_____/21:N0000165
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iqGXaOnHXU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iqGXaOnHXU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-021-95285-z" target="_blank" >10.1038/s41598-021-95285-z</a>
Alternative languages
Result language
angličtina
Original language name
Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals
Original language description
The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of bla(KPC)-carrying plasmids; 19 out of 25 bla(KPC)-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining bla(KPC)-carrying plasmids were multireplicon, while one plasmid couldn't be typed. Additionally, phylogenetic analysis confirmed the spread of bla(KPC)-carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of bla(KPC)-carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
15732
UT code for WoS article
000684194100003
EID of the result in the Scopus database
2-s2.0-85112022474