Biomarkers in Head and Neck Carcinomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F22%3A10439500" target="_blank" >RIV/00216208:11140/22:10439500 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-030-84432-5_4" target="_blank" >http://dx.doi.org/10.1007/978-3-030-84432-5_4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-84432-5_4" target="_blank" >10.1007/978-3-030-84432-5_4</a>
Alternative languages
Result language
angličtina
Original language name
Biomarkers in Head and Neck Carcinomas
Original language description
Current and emerging biomarkers in primary head and neck carcinoma have diagnostic, prognostic, and predictive value. Following histomorphological evaluation, immunohistochemical markers, and molecular methods may help to differentiate between numerous tumor types. Phenotypic markers which are related with squamous and neuroendocrine differentiation or viral infections are helpful in upper aerodigestive tract carcinomas. Additionally, recently described molecular alterations, such as NUT translocation or SMARCB1 and IDH2 mutations, aid in classifying them better. The prognostic importance of high-risk human papillomavirus positivity which is prominent in the oropharynx and is possible in some other sites in head and neck and the diagnostic utility of the detection of latent Epstein-Barr virus infection in nasopharyngeal carcinoma or lymphoepithelial carcinoma is notified. Immunohistochemical markers together with certain molecular alterations, especially specific translocations in salivary glands, are helpful for overcoming diagnostic difficulties and for increasingly guiding the utilization of targeted therapies. Hereby, this chapter reviews the latest developments in biomarkers in primary head and neck carcinomas with a focus on distinctive phenotypic and molecular aspects.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Biomarkers in Carcinoma of Unknown Primary
ISBN
978-3-030-84431-8
Number of pages of the result
32
Pages from-to
67-98
Number of pages of the book
483
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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