Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F23%3A10456502" target="_blank" >RIV/00216208:11140/23:10456502 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/23:10456502
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lbFXRVzmnp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lbFXRVzmnp</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphys.2022.1094199" target="_blank" >10.3389/fphys.2022.1094199</a>
Alternative languages
Result language
angličtina
Original language name
Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia
Original language description
"Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of sepsis and developing new treatment strategies, reliable and clinically relevant animal models of the disease are necessary. In this review, two large animal (porcine) models of sepsis induced by either peritonitis or bacteremia are introduced and their strong and weak points are discussed in the context of clinical relevance and other animal models of sepsis, with a special focus on cardiovascular and immune systems, experimental design, and monitoring. Especially for testing new therapeutic strategies, the large animal (porcine) models represent a more clinically relevant alternative to small animal models, and the findings obtained in small animal (transgenic) models should be verified in these clinically relevant large animal models before translation to the clinical level.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Physiology
ISSN
1664-042X
e-ISSN
1664-042X
Volume of the periodical
13
Issue of the periodical within the volume
January
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000921842400001
EID of the result in the Scopus database
2-s2.0-85146911040